Considering that in actual practice many patients regain weight after they initially lose it, it is unlikely that an individual would continue to restrict calories for 10 years, ultimately resulting in a negative weight. The second section, “What You Can Do To Lose Weight,” discussed assessing and adjusting diet and caloric intake based on actual results, without the use of a calculator. In Reply Although the points raised by Dr Allison and colleagues have merit (weight loss in the long-term is more varied than the simple formula presented), the goal of the Patient Page is to provide easily understood information and accessible guidelines for the majority of patients. Bredlau C, Lettieri S Pennington Biomedical Research Center. Can a weight loss of one pound a week be achieved with a 3500-kcal deficit? commentary on a commonly accepted rule. Quantification of the effect of energy imbalance on bodyweight.

Dr Heymsfield reported serving on an advisory board for Medifast.

Dr Thomas also reported receiving funds from Jenny Craig. Dr Allison also reported receiving personal fees from Kellogg Company and Weight Watchers collaborating on a project funded by the nonprofit International Life Sciences Foundation to predict weight changes in response to changes in energy balance receiving or will receive fees from the nonprofit Nutrition Science Initiative, the Federal Trade Commission, Sage Publications, and Eisai and receiving institutional grants, contracts, or unrestricted gifts awarded to the University of Alabama from Medifast and Cooking Light magazine. Drs Allison and Thomas reported receiving grant support from the National Institutes of Health for teaching applications of mathematical sciences to obesity research. Allison, PhD, Department of Biostatistics, University of Alabama, 1665 University Blvd, Birmingham, AL 35294 (dallison Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Heymsfield, MD Author Affiliations: Nutrition Obesity Research Center, University of Alabama, Birmingham (Allison) Center for Quantitative Obesity Research, Montclair State University, Montclair, New Jersey (Thomas) Pennington Biomedical Research Center, Baton Rouge, Louisiana (Heymsfield).

A more accurate public message would be to suggest that both health care workers and the public use either of the 2 freely available web-based applications to create realistic weight loss expectations as a function of energy intake or expenditure changes.2,4 David B. Such inaccuracies can lead to erroneous judgments regarding the effects of clinical and public health measures. Calorie rule would yield a negative body weight, whereas the weight loss prediction of the dynamic model would stabilize at a 31-lb loss after 3 years.

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